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Target intelligence / Profile preview
Keratin-associated protein 13-4 (KRTAP13-4)
- Target
- KRTAP13-4
- Molecular classification
- Other, keratin-associated protein, structural protein
01
Overview
Keratin-associated protein 13-4 is a member of the KAP (keratin-associated proteins) family, which forms a critical part of the interfilamentous matrix embedding keratin intermediate filaments within the hair cortex. Through abundant cysteine residues, KRTAP13-4 participates extensively in disulfide bond cross-linking with hair keratins, thereby contributing to the formation of a rigid and resilient hair shaft. KRTAP13-4 is a structural, non-enzymatic protein encoded by a gene located on human chromosome 21. Its primary role is in hair biology, and there is no evidence supporting its function as a classical therapeutic target such as a receptor, enzyme, transporter, or transcription factor[4].
- Other names
- Keratin associated protein 13-4KAP13.4KRTAP13-4
02
Biological functions
Structural component of hair cortexContributes to the formation of hair shaft through disulfide bond cross-linking with keratin filaments
03
Disease associations
Other (no directly known association to major disease categories; associated generally with hair biology, and possibly minor involvement in rare conditions or syndromes)
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