Keratin-associated protein 17-1 (KRTAP17-1)

Keratin-associated protein 17-1 is a structural protein belonging to the ultrahigh sulfur subgroup of the keratin-associated protein (KAP) family[1]. KAPs form an interfilamentous matrix around keratin intermediate filaments, contributing to the rigidity and resilience of hair shafts through extensive disulfide cross-linking[1]. KRTAP17-1 is primarily expressed in the hair cortex and is not recognized as a classical receptor, enzyme, transporter, or therapeutic target[1]. Its primary biological function is the stabilization and structural formation of hair fibers, and mutations or altered expression may be genetically associated with conditions like limited scleroderma, but the mechanistic details remain unclear and no known drugs target this protein[1]. KRTAP17-1 is not a therapeutic target or receptor but a structural component in hair[1]. It is part of the "ultrahigh sulfur" KAPs, notable for their cysteine-rich sequences and involvement in hair structure[1]. Clinical significance is limited; primarily studied in the context of hair biology and some genetic associations, but not as a direct disease target[1]. There is no evidence for drug targeting, biomarker use, or known safety concerns. Studies on related family members (e.g., KRTAP5-5) suggest potential indirect roles in cytoskeletal regulation in cancer biology, but there is no direct evidence involving KRTAP17-1 itself[3].

Other names

Keratin-associated protein 17-1KRTAP17-1KAP17.1KRTAP16.1Keratin-associated protein 16.1