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Keratin associated protein 19-4 (KAP19-4)
- Target
- KAP19-4
- Molecular classification
- Keratin-associated protein, Structural protein, Intermediate filament-associated protein
01
Overview
Keratin associated protein 19-4 is a structural protein encoded by the KRTAP19-4 gene and belongs to the family of keratin-associated proteins found predominantly in hair. It is a high-sulfur protein that participates in forming a matrix surrounding the hair keratin intermediate filaments in the hair cortex, strengthening the hair shaft through extensive disulfide cross-linking with cysteine-rich keratins[1][3][4][9]. While it plays a crucial role in hair structure and mechanical properties, it is not considered a therapeutic target, nor is it known to be directly involved in major human diseases outside the context of hair biology[1][4].
- Other names
- KRTAP19-4KAP19.4
02
Mechanism of action
Not applicable (no drugs known to target this protein)
03
Biological functions
Structural support of hairFormation of hair shaft rigidity and strength through disulfide bond crosslinking with keratin filaments[1][3][4][9]
04
Disease associations
No direct evidence as a disease-associated target, but keratin-associated proteins as a group may influence hair texture and related inherited disorders[1][4]Association to Three M Syndrome 1 (unclear mechanistic relationship)[1]
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