Keratin-associated protein 19-8 (KRTAP19-8)

Keratin-associated protein 19-8 (KRTAP19-8) is a member of the keratin-associated protein family, which is essential for the structural properties of hair. In the hair cortex, keratin intermediate filaments are cross-linked into a robust, resistant matrix by keratin-associated proteins, mediated by disulfide bonding with high cysteine content. Family members are primarily localized to the cytosol within hair-producing cells and do not have recognized signaling, catalytic, or receptor activities. KRTAP19-8 is a structural protein key to hair fiber formation, classified among high-sulfur or high-glycine/tyrosine KRTAPs that give hair its physical properties. No known drugs target KRTAP19-8, and it is not used as a biomarker or considered a therapeutic target. The main biological relevance is restricted to hair and fur morphology. There is no evidence that KRTAP19-8 plays a major direct role in human disease or pharmacotherapy. The "molecular classification" is "Other" since this protein does not fit receptor, enzyme, ion channel, transporter, or transcription factor categories.

Other names

KRTAP19-8KAP19.8keratin-associated protein 19-8