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Keratin-associated protein 20-2 (KRTAP20-2)
- Target
- KRTAP20-2
- Molecular classification
- Other (structural protein; high glycine-tyrosine keratin-associated protein)
01
Overview
Keratin-associated protein 20-2 (KRTAP20-2) is a member of the high glycine-tyrosine family of keratin-associated proteins, primarily expressed in the secondary hair follicles of mammals such as goats, sheep, and humans[1]. It encodes a small structural protein (62–65 amino acids in mammals) rich in glycine, tyrosine, serine, and cysteine. KRTAP20-2 is not expressed in major internal organs but is highly specific to hair follicles involved in fiber production[1]. In livestock, genetic variants of KRTAP20-2 are associated with differences in fiber traits such as cashmere weight, fiber length, and curliness, making it a candidate marker gene for breeding programs[1][2]. There is no current evidence indicating KRTAP20-2 is involved in human disease or that it is a therapeutic target. Its primary biological function is to contribute to the physical properties of hair and wool fibers through its role in hair shaft structure[1][2].
- Other names
- KAP20-2KAP20.2keratin-associated protein 20-2KRTAP20-2
02
Biological functions
Hair and wool fiber structureSecondary hair follicle-specific proteinContributes to fiber diameter and curlinessInvolved in hair keratinization
03
Disease associations
Other (associated with fiber/hair traits in livestock; no established disease role in humans)
04
Biomarkers
Variation in KRTAP20-2 can serve as a genetic marker for fiber properties in goats and sheep[1][2]
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