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Target intelligence / Profile preview
Keratin-associated protein 21-2 (KRTAP21-2)
- Target
- KRTAP21-2
- Molecular classification
- Other (Keratin-associated protein)
01
Overview
Keratin-associated protein 21-2 (KRTAP21-2) is a member of the large KRTAP gene family, which encodes proteins involved in the structure and formation of hair, wool, and fur. These proteins are expressed abundantly in the hair-producing cells (trichocytes) and interact closely with keratin intermediate filaments to form a rigid, cross-linked hair shaft matrix. Their amino acid composition (enriched for sulfur-containing cysteine or glycine/tyrosine, depending on subfamily) is critical for determining the mechanical strength, thickness, and texture of hair fibers[2][4]. KRTAP21-2 is classified as a high-sulfur (or ultra-high-sulfur) KRTAP, based on its sequence characteristics. Although crucial for the normal assembly and properties of mammalian hair, KRTAP21-2 is not considered a pharmacological target, receptor, enzyme, or signaling protein, and has no direct therapeutic or disease-modifying roles[2][4].
- Other names
- KRTAP21-2KAP21.2keratin associated protein 21-2
02
Mechanism of action
Not applicable, as KRTAP21-2 is not considered a druggable therapeutic target.
03
Biological functions
Plays a structural role in the formation and properties of hair fibers, specifically by binding to keratins within hair shaft cells (trichocytes) to help assemble the rigid hair shaft matrix[2][4].Important for fiber thickness, curliness, and mechanical properties of hair and wool[2].
04
Disease associations
No direct disease associations are reported for this gene, but KRTAP family genes in general impact hair disorders (such as wool properties in sheep and potentially human hair structure abnormalities)[2].
05
Safety considerations
None known; no therapeutic targeting, thus no described safety or toxicity profile.
06
Interacting drugs
None known; no drugs reported to target or modulate KRTAP21-2.
07
Biomarkers
None specified for this gene.
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