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Target intelligence / Profile preview
Keratin-associated protein 21-3 (KRTAP21-3)
- Target
- KRTAP21-3
- Molecular classification
- Other (structural hair matrix protein), Keratin-associated protein family
01
Overview
Keratin-associated protein 21-3 is a member of the keratin-associated protein (KRTAP) family, which, together with keratins, is a principal structural component of human hair and nails[3][2][4]. These proteins are important in forming the rigid and resistant structure of the hair shaft by providing a disulfide-bonded crosslinked matrix around keratin filaments, lending mechanical strength and resilience to hair[4][3][2]. The KRTAP gene family is diverse, with different members contributing to variations in hair properties such as thickness and curliness in different species[2]. KRTAP21-3 specifically is categorized with other KRTAPs based on its cysteine, glycine, and tyrosine content, influencing its specific role in hair structure[2][5]. There is no evidence that KRTAP21-3 is a therapeutic target, nor is it implicated in major human diseases or used in drug development or clinical diagnostics.
- Other names
- Keratin-associated protein 21-3KRTAP21-3KAP21.3keratin-associated protein 21-3
02
Biological functions
Hair shaft formationHair fiber rigidity and resistanceStructural organization of hair matrix
03
Disease associations
Other (Not directly implicated in major disease categories; mutations may hypothetically alter hair structure, but not recognized as an established disease gene)
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