Keratin-associated protein 22-1 (KRTAP22-1)

Keratin-associated protein 22-1 (KRTAP22-1) is a member of the keratin-associated protein gene family, which encodes key structural proteins found in hair, wool, and other fibers of mammals[1][4]. KRTAP22-1 is classified within the subgroup of high glycine-tyrosine (HGT) KAP proteins, which form a semi-rigid matrix with keratin intermediate filaments to provide mechanical strength and flexibility to fibers[1][4]. Variation in the KRTAP22-1 gene, particularly in sheep, influences important fiber traits such as wool yield and mean fiber curvature, making it a marker of interest in animal breeding[1]. KRTAP22-1 is not a receptor, enzyme, or drug target, but is fundamental to hair and wool structure and its associated mechanical properties[1][4].

Other names

KAP22.1Keratin-associated protein 22-1KRTAP22-1