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Target intelligence / Profile preview
Keratin-associated protein 22-2 (KRTAP22-2)
- Target
- KRTAP22-2
- Molecular classification
- Other (Keratin-associated protein)
01
Overview
Keratin-associated protein 22-2 (KRTAP22-2) is a small structural protein, part of the keratin-associated protein (KAP) family, which forms the interfilamentous matrix critical for hair and wool fiber structure[1][2][4][5]. KRTAP22-2 interacts with hair keratins via disulfide bonds through its abundant cysteine residues, thereby contributing to the rigidity and resistance of the hair shaft[2][4][5]. Genetic variation in KRTAP22-2 has been linked to changes in fiber characteristics such as mean fiber diameter in cashmere goats, making it a candidate marker for fiber quality in breeding programs[1]. There is no evidence that KRTAP22-2 acts as a classical drug target (e.g., receptor, enzyme, transporter), nor that it is involved in major human diseases, though alterations in its sequence may influence externally visible traits[1][2][5].
- Other names
- KRTAP22-2KAP22.2keratin associated protein 22-2
02
Biological functions
Hair and wool structure formationinterfilamentous matrix assemblyrigidity and strength contribution of hair shaft
03
Disease associations
Other (structural trait association, no direct evidence of major disease association except mention of Three M Syndrome 1 in a predicted context)
04
Biomarkers
Candidate molecular marker for cashmere fiber traits in goats (e.g., mean fiber diameter)
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