Keratin-associated protein 24-1 (KRTAP24-1)

Keratin-associated protein 24-1 (KRTAP24-1) is a structural protein encoded by the KRTAP24-1 gene, typically expressed in scalp hair, particularly within the middle and upper regions of the hair cuticle[1][2][3][7]. The protein is characterized by a high content of serine, proline, and tyrosine, and a unique repeat motif, suggesting it plays a specific role in hair cuticle differentiation and maintaining cuticle integrity[2]. It contributes to the organization and stabilization of keratin intermediate filaments in the hair cortex by forming an interfilamentous matrix essential for the rigidity and resilience of hair fibers through disulfide linkages with keratins[3][7]. Variations in KRTAP24-1 have been implicated in fiber properties in livestock, and expression correlates with hair follicle growth cycles in some species[2]. This protein is not known as a therapeutic target, nor are there specific drugs or safety concerns associated with it in current literature[1][2].

Other names

KAP24.1keratin associated protein 24-1KR241_HUMAN