Target intelligence / Profile preview

Keratin-associated protein 29-1 (KRTAP29-1)

Target
KRTAP29-1
Molecular classification
Other, Structural protein, Keratin-associated protein, High-sulfur protein
01

Overview

Keratin-associated protein 29-1 (KRTAP29-1) is a member of the large keratin-associated protein (KRTAP) gene family, which consists of proteins that interact with hair keratins to form and determine the structural properties of hair fibers, wool, and fur in mammals. Members of the KRTAP29 subfamily, including KRTAP29-1, are categorized as high-sulfur proteins due to their cysteine-rich amino acid composition, which enables them to form disulfide bonds important for the mechanical strength and resilience of hair. These proteins are expressed mainly in hair follicles where they help shape the morphological characteristics of hair but are not considered receptors, enzymes, drug targets, or disease biomarkers. Their main functional role is structural, and there is no evidence indicating they are used as therapeutic targets or are associated directly with common diseases[1][2][3].

Other names
KRTAP29-1KAP29.2Keratin-associated protein 29-1Keratin-associated protein 29.2keratin associated like protein 29-1keratin-associated protein 29.2
02

Biological functions

Structural support for hair fibersInteraction with keratin intermediate filaments in hair-producing cells (trichocytes)Contributing to physical properties of hair such as strength, flexibility, thickness, and curliness
03

Disease associations

Other (no strong or direct evidence for involvement in major diseases; mentioned only in the context of genetic association with rare conditions like Three M Syndrome 1, with unclear direct relevance)

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