Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Keratin-associated protein 3-1 (KRTAP3-1)
- Target
- KRTAP3-1
- Molecular classification
- Other (structural protein, keratin-associated protein, high sulfur KAP family)
01
Overview
Keratin-associated protein 3-1 (KRTAP3-1) is a member of the keratin-associated protein (KAP) family, specifically classified within the high sulfur KAP subgroup. These proteins form an interfilamentous matrix with hair keratin intermediate filaments in the hair cortex, contributing substantially to the structural rigidity and resilience of hair fibers by establishing extensive disulfide bonds with keratin proteins. Each KAP family member, including KRTAP3-1, possesses distinctive amino- and carboxyl-terminal sequences, and the human KRTAP3-1 gene maps to a cluster on chromosome 17q12-q21. Although KRTAP3-1 is a structurally vital gene for hair biology, it is not recognized as a therapeutic target, receptor, enzyme, transporter, or transcription factor, and there are no currently known drugs or therapeutic interventions directly interacting with it.
- Other names
- Keratin-associated protein 3-1KRTAP3-1KAP3.1Keratin associated protein 3-1KRTAP3.1High sulfur keratin-associated protein 3.1high sulfur keratin-associated protein 3.1keratin-associated protein 3.1
02
Biological functions
Structural molecule activityhair fiber matrix formationhair shaft rigidity and resistance through disulfide bond cross-linking with hair keratin
03
Disease associations
Other (implicated as contributing to the structure of hair, associated with disorders such as Björnstad syndrome and monilethrix)
Beyond the preview
Go deeper on Keratin-associated protein 3-1 (KRTAP3-1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Keratin-associated protein 3-1 (KRTAP3-1).