Keratin associated protein 3-1 pseudogene

Keratin associated protein 3-1 pseudogene refers to a genomic region related to the KRTAP3-1 gene, which encodes a high-sulfur keratin-associated protein involved in the formation and structure of hair fibers[1][4][6]. However, as a pseudogene, this locus does not code for a functional protein due to one or more disabling mutations, such as premature stop codons or frameshifts[4][6]. Pseudogenes like this are generally regarded as non-functional remnants of duplicated or once-active genes. They have no known biological function, role in human disease, or relevance as a therapeutic target. The keratin-associated proteins (KAPs/KRTAPs) are structural components of hair fibers, grouped by sulfur content and sequence similarity, but functional information pertains to protein-coding family members, not pseudogenes[1][5][4]. The suffix "pseudogene" and presence in modern nomenclature guides make clear that this entry is not for an active protein or receptor and should not be regarded as a therapeutic target[4][6]. No drug interactions, biological roles, biomarker relevance, or safety concerns are linked to this pseudogene.

Other names

KRTAP3-1Pkeratin-associated protein 3-1 pseudogene