Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Keratin-associated protein 4-1 (KRTAP4-1)
- Target
- KRTAP4-1
- Molecular classification
- Other, Keratin-associated protein family, Ultrahigh sulfur keratin-associated protein
01
Overview
Keratin-associated protein 4-1 is a member of the keratin-associated protein family, specifically the ultrahigh sulfur subfamily. These proteins interact with keratin intermediate filaments in the hair cortex, providing structural rigidity and resistance to the hair shaft through extensive disulfide cross-linking with hair keratins due to their abundant cysteine content. KRTAP4-1 is mainly involved in hair fiber structure and is not recognized as a therapeutic target, receptor, enzyme, or transporter. Its gene is clustered on chromosome 17q12-q21 among other keratin-associated protein genes.
- Other names
- KAP4.1KAP4.10KRTAP4-10KRTAP4.10Keratin-associated protein 4-10Keratin-associated protein 4.10Ultrahigh sulfur keratin-associated protein 4.10keratin associated protein 4-10keratin-associated protein 4.1
02
Mechanism of action
None known
03
Biological functions
Structural component of hair cortexFormation of keratin matrixDisulfide bond cross-linking in hair shaft
04
Disease associations
OtherPossibly related to hair structure disordersThree M syndrome 1 is listed as associated, but evidence is limited and not direct
Beyond the preview
Go deeper on Keratin-associated protein 4-1 (KRTAP4-1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Keratin-associated protein 4-1 (KRTAP4-1).