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Keratin-associated protein 4-3 (KRTAP4-3)
- Target
- KRTAP4-3
- Molecular classification
- Structural protein, Keratin-associated protein, Member of KRTAP type 4 family
01
Overview
Keratin-associated protein 4-3 is a member of the KRTAP type 4 family, found in the hair cortex. It is part of an interfilamentous matrix embedding hair keratin intermediate filaments, contributing to the formation of a rigid and resistant hair shaft. This structural property is achieved through extensive disulfide bonding with the cysteine-rich hair keratins, especially involving high-sulfur keratin-associated proteins. KRTAP4-3 is coded by the KRTAP4-3 gene (HGNC:18908, NCBI Gene:85290) and is predicted to be cytosolic. Its mutations have minor associations with rare genetic syndromes, but it is not implicated in major disease pathways nor is it pursued for drug development[1][3][6][7].
- Other names
- KRTAP4-3KAP4.3KRTAP4.3Keratin-associated protein 4.3Ultrahigh sulfur keratin-associated protein 4.3keratin-associated protein 4-3keratin-associated protein 4.3ultrahigh sulfur keratin-associated protein 4.3
02
Biological functions
Hair shaft formationDisulfide bond cross-linking within hair cortexContributes to mechanical rigidity/resistance of hair
03
Disease associations
Other (No evidence as a direct disease target; associated with hair structure and minor connection to Cystadenofibroma and Three M Syndrome 1)
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