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Keratin-associated protein 4-4 (KRTAP4-4)
- Target
- KRTAP4-4
- Molecular classification
- Other (keratin-associated protein family; structural matrix protein)
01
Overview
Keratin-associated protein 4-4 (KRTAP4-4) is a protein encoded by the KRTAP4-4 gene in humans. It belongs to the keratin-associated protein (KAP) family, which is characterized by forming the matrix that embeds keratin intermediate filaments in the hair cortex[2][5][6][8][9]. KAP molecules, including KRTAP4-4, play an essential role in determining the physical properties of hair fibers such as resilience and flexibility, but have no established function as enzymes, receptors, channels, or targets for drug development[2][7][8][9]. They are particularly notable for their high sulfur content, which contributes to disulfide bond formation and the structural integrity of hair and wool[7][9].
- Other names
- KRTAP4-4KAP4.4KAP4.13Keratin-associated protein 4.4Keratin-associated protein 4.13KRTAP4-13Ultrahigh sulfur keratin-associated protein 4.4Ultrahigh sulfur keratin-associated protein 4.13
02
Biological functions
Structural support for hair fibers (provides matrix for keratin intermediate filaments)Influences fiber physical properties such as strength, resilience, and texture
03
Disease associations
Other (no established roles in major diseases as a direct causative or therapeutic target; associated generally with hair/wool traits and quality)
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