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Keratin-associated protein 4-5 (KRTAP4-5)
- Target
- KRTAP4-5
- Molecular classification
- Other (keratin-associated protein family, ultrahigh sulfur subgroup)
01
Overview
Keratin-associated protein 4-5 (KRTAP4-5) is a structural protein belonging to the keratin-associated protein (KAP) family, specifically the ultrahigh sulfur subgroup. These proteins are important in hair biology, forming a matrix around keratin intermediate filaments in the hair cortex. Their extensive disulfide bond cross-linking with cysteine-rich hair keratins enhances the rigidity and resistance of the hair shaft. Although genetic variants are linked to some diseases, KRTAP4-5 is not considered a therapeutic target, receptor, enzyme, or signaling molecule but rather a tissue-specific structural component important for normal hair structure and integrity
- Other names
- Keratin-associated protein 4.5KAP4.5KRTAP4.5ultrahigh sulfur keratin-associated protein 4.5
02
Biological functions
Structural component of hair fiberContributes to the matrix embedding hair keratin intermediate filamentsEssential for formation of rigid and resistant hair shaft via disulfide cross-linking with hair keratins
03
Disease associations
Other (associated with nodular basal cell carcinoma and colon adenoma, but not a direct causative or therapeutic target)
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