Keratin-associated protein 4-7 (KRTAP4-7)

Keratin-associated protein 4-7 (KRTAP4-7) is a structural protein found predominantly in the hair cortex, where it forms part of the interfilamentous matrix that surrounds hair keratin intermediate filaments[1]. KRTAP4-7 is classified as an **ultrahigh sulfur keratin-associated protein** due to its high cysteine content, enabling extensive disulfide bond cross-linking with hair keratins, which is essential for the formation of a rigid and resistant hair shaft[1][4]. KRTAP4-7 belongs to a large family of structurally related proteins, unique to mammals, that enable mechanical strength and resilience of hair fibers[2][4]. Variations in KRTAPs have been associated with differences in hair properties, though KRTAP4-7 has not been established as a direct therapeutic target for any disease. While its gene may appear in studies of inherited hair disorders or as a locus of structural genetic variation, it plays an indirect or structural role rather than serving as a classical therapeutic target[1][4].

Other names

KAP4.7KRTAP4.7Keratin associated protein 4-7Ultrahigh sulfur keratin-associated protein 4.7Putative keratin-associated protein 4-X