Keratin associated protein 5-11 pseudogene

Keratin associated protein 5-11 pseudogene (ENSG00000232668) is a human pseudogene from the keratin associated protein (KRTAP) gene family. KRTAP genes encode proteins that interact with hair keratin, forming a matrix essential for hair shaft formation where high-sulfur and high-glycine/tyrosine KRTAPs cross-link hair keratin filaments via disulfide bonds[3][4][6]. However, the 5-11 variant described here is a pseudogene, meaning it has lost its protein-coding ability and is not expressed as a functional protein[1][2][6]. There is no evidence of functional role, disease involvement, or therapeutic relevance for this pseudogene in humans. Key context: Keratin associated protein genes play a role in hair structure but only if they are functional protein-coding genes[2][3][4]. Pseudogenes, by definition, are generally non-functional remnants of evolution and are not included in catalogs of druggable or disease-related targets[1]. The related functional gene "keratin associated protein 5-11" (KRTAP5-11) may appear in some resources, but "pseudogene" status distinguishes this entry as non-coding and non-therapeutic[6]. Therapeutic and biomarker information is not applicable for pseudogenes unless specifically linked to disease (which is not the case here). This entry should be considered not a valid therapeutic or biological target due to its pseudogene status[1][2][6].

Other names

KRTAP5-11 pseudogeneKRTAP5-11PKAP5.11 pseudogene