Keratin-associated protein 5-2 (KRTAP5-2)

Keratin-associated protein 5-2 (KRTAP5-2) is a member of the keratin-associated protein (KRTAP) family, specifically categorized among the ultrahigh sulfur KAPs. This protein is primarily expressed in humans as a structural component of hair. KRTAP5-2 interacts with hair keratin intermediate filaments within the hair cortex, contributing to the formation of a rigid and resilient hair shaft by establishing extensive disulfide bond cross-linking, which is facilitated by its high cysteine content. While essential in hair biology, KRTAP5-2 is not recognized as a therapeutic target or receptor, enzyme, or transporter. There is no evidence of drug interaction, role as a biomarker, or involvement in common human diseases beyond its normal biological context[1][3]. **Note:** If you are seeking information on KRTAP family proteins and disease, research mostly concerns their structural roles in hair and, in rare cases, related hair disorders. Most work with cancer and cytoskeletal dynamics references other family members like KRTAP5-5[2], not specifically KRTAP5-2.

Other names

KAP5-8KAP5.2KRTAP5-8KRTAP5.2KRTAP5.8Keratin-associated protein 5-8Keratin-associated protein 5.2Keratin-associated protein 5.8Ultrahigh sulfur keratin-associated protein 5.2