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Target intelligence / Profile preview
Keratin-associated protein 5-7 (KRTAP5-7)
- Target
- KRTAP5-7
- Molecular classification
- Structural protein, Keratin-associated protein family
01
Overview
Keratin-associated protein 5-7 is a member of the keratin-associated protein (KRTAP) family, which are structural proteins primarily located in the hair cortex. These proteins form an interfilamentous matrix that embeds hair keratin intermediate filaments, and are crucial for hair fiber formation and strength. KRTAP5-7 contains a high sulfur content, contributing to the stability and mechanical properties of hair by forming disulfide bonds with keratin filaments. There is no evidence that KRTAP5-7 acts as a therapeutic target, receptor, enzyme, transporter, or is directly implicated in human disease. Its main biological role is in keratinization and normal hair fiber development[3][6].
- Other names
- Keratin-associated protein 5-7KRTAP5-7KAP5-7KAP5.3KRTAP5.3KRTAP5.7KRTAP5-3Keratin-associated protein 5-3Keratin-associated protein 5.3Keratin-associated protein 5.7Ultrahigh sulfur keratin-associated protein 5.7
02
Biological functions
KeratinizationHair morphogenesis
03
Disease associations
Associated with hair structureNot established in human disease pathogenesis
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