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Keratin-associated protein 5-9 (KRTAP5-9)
- Target
- KRTAP5-9
- Molecular classification
- Other (keratin-associated protein; matrix protein)
01
Overview
Keratin-associated protein 5-9 is a matrix protein found in the cortex of hair fibers, where it embeds the keratin intermediate filaments and helps confer strength and rigidity to the hair shaft. It achieves this through extensive disulfide bond cross-linking due to abundant cysteine residues. KRTAP5-9 is classified among the high-sulfur keratin-associated proteins, a family essential for hair formation and mechanical properties. It is not associated with therapeutic targeting, disease diagnostics, or drug interactions[3][5][11].
- Other names
- KRTAP5-9KAP5.9KRN1KRTAP5-1UHSK1UHS KerAUHS keratin AKeratin, cuticle, ultrahigh sulfur 1Keratin, ultra high-sulfur matrix protein AUltrahigh sulfur keratin-associated protein 5.9
02
Mechanism of action
None known (not targeted therapeutically)
03
Biological functions
Structural component of hair cortexProtein-protein binding activityEpidermis/hair development
04
Disease associations
Other (no direct disease association; sometimes included in generic hair/skin development or rare syndromes such as Three M syndrome 1 not directly mechanistically linked)
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