Keratin-associated protein 6-1 (KRTAP6-1)

Keratin-associated protein 6-1 is a structural protein found in the hair and wool fibers of mammals, especially studied in sheep and humans. It belongs to the keratin-associated protein (KAP) family and is characterized by its role in forming the interfilamentous matrix that embeds hair keratin intermediate filaments in the hair cortex[1][2][3]. KRTAP6-1 is expressed predominantly in hair follicle-associated structures, including dermal papillae and root sheaths, where it contributes to properties such as fiber diameter and strength, especially in wool-producing species[1]. This protein is not a conventional therapeutic target but is of interest for studies in textile biology and animal breeding[1][3][5].

Other names

KAP6.1C21orf103keratin associated protein 6-1