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Target intelligence / Profile preview
Keratin-associated protein 8-1 (KRTAP8-1)
- Target
- KRTAP8-1
- Molecular classification
- Other (Structural protein; Keratin-associated protein family)
01
Overview
Keratin-associated protein 8-1 (KRTAP8-1) is a member of the KRTAP gene family, which consists of proteins crucial for the mechanical and structural properties of hair, wool, and fur in mammals[1][3][4]. KRTAP8-1 belongs to the high glycine-tyrosine content subgroup and forms part of the matrix linking keratin intermediate filaments in trichocytes, the hair-producing cells, thereby determining the characteristics of hair fibers[1][3][4]. This protein can bind directly to certain hair keratins, such as keratin K85, and its homologs have even been identified in non-mammalian species, indicating potential physiological roles beyond hair formation[1]. While KRTAP8-1 is fundamental in hair biology, it is not a recognized drug target, nor is it directly implicated in disease or used as a clinical biomarker[1][3][4].
- Other names
- KRTAP8-1KAP8.1KRTAP8.1High glycine-tyrosine keratin-associated protein 8.1keratin-associated protein 8-1
02
Mechanism of action
Not applicable (This protein is not a known therapeutic target and there are no drugs reported to interact with it)
03
Biological functions
Structural integrity and assembly of hair shaftComponent of the interfilamentous matrix that links and stabilizes keratin intermediate filaments in trichocytes (hair-producing cells)
04
Disease associations
Other (No established disease link; possible association with hair fiber traits and characteristics such as fiber thickness or curliness in wool, but no direct implication in disease)
05
Safety considerations
None reported (No known safety concerns or therapeutic challenges associated with targeting this protein)
06
Interacting drugs
None reported
07
Biomarkers
None reported (No clinical biomarkers for patient selection or efficacy monitoring associated with KRTAP8-1)
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