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Target intelligence / Profile preview
Keratin-associated protein 9-2 (KRTAP9-2)
- Target
- KRTAP9-2
- Molecular classification
- Other (keratin-associated protein, structural protein)
01
Overview
Keratin-associated protein 9-2 (KRTAP9-2) is a member of the keratin-associated protein family, classified under the ultrahigh sulfur group due to its high cysteine content. KRTAP9-2 forms part of the matrix that embeds keratin intermediate filaments, contributing to the structure and mechanical strength of hair and, to a lesser extent, nails. These proteins are extensively cross-linked to keratins via disulfide bonds, which are critical for the rigidity and resilience of hair fibers. There is no evidence that KRTAP9-2 serves as a therapeutic drug target, nor are there known drugs or direct disease associations for this specific protein[2][4].
- Other names
- KAP9.2KRTAP9.2Keratin-associated protein 9.2ultrahigh sulfur keratin-associated protein 9.2
02
Biological functions
Hair and nail structureformation of interfilamentous matrix for hair keratinstabilization of keratin intermediate filaments
03
Disease associations
Other (no direct disease association identified; broader KRTAP family not generally therapeutic targets—note: some related KRTAPs have been loosely explored as skin disease marker candidates)
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