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Target intelligence / Profile preview
Keratin-associated protein 9-6 (KRTAP9-6)
- Target
- KRTAP9-6
- Molecular classification
- Other (structural protein), Keratin-associated protein
01
Overview
Keratin-associated protein 9-6 (KRTAP9-6) is a protein encoded by the KRTAP9-6 gene, and is a member of the keratin-associated protein (KAP) family. KRTAP9-6 is rich in cysteine residues, facilitating extensive disulfide bond cross-linking with hair keratins, which strengthens and stiffens the hair shaft structure[4][7]. It belongs to the high/ultrahigh sulfur KAP subgroup[7]. Predicted to be located in the cytosol, KRTAP9-6 is mainly of structural importance in the hair cortex and does not function as an enzyme, receptor, transporter, or any recognized therapeutic target[4][7][8]. There is no current evidence of KRTAP9-6 being directly involved in major diseases or serving as a drug target, biomarker, or pharmacological safety concern.
- Other names
- KAP9.6KRTAP9.6KRTAP9L2Keratin-associated protein 9-like 2putative keratin-associated protein 9-2-like 2
02
Biological functions
Contributes to hair shaft rigidity and resistanceForms extensive disulfide bonds with hair keratins
03
Disease associations
Other (general genetic associations; some references to syndromes involving hair but no clear disease causation)
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