Keratin proteins and mucopolysaccharides in eccrine sweat ducts

Keratin proteins and mucopolysaccharides within the eccrine sweat ducts represent a composite pharmacological target primarily utilized in the treatment of hyperhidrosis (Hölzle, 2002). Keratins provide the structural framework of the ductal epithelium, while mucopolysaccharides (glycosaminoglycans) form a protective lining or glycocalyx within the lumen (Quinton, 1983). When aluminum-based salts are applied to the skin, they dissolve in sweat and enter the duct, where the higher pH causes the aluminum ions to precipitate (Pariser & Ballard, 2014). These ions cross-link with the keratin fibers and mucopolysaccharides to form a physical, gel-like plug that occludes the ductal opening (Shelley & Hurley, 1975). This occlusion prevents the egress of sweat to the skin surface, effectively managing conditions like hyperhidrosis (Scholes et al., 2011). Over time, these plugs are naturally shed through the normal process of epidermal turnover and sweat pressure (Hölzle, 2002).

Other names

Eccrine ductal proteinsSweat duct mucinsDuctal keratin-glycosaminoglycan complexAntiperspirant plug components

Physical occlusion of the eccrine sweat duct through the formation of a gel-like precipitate (plug) composed of aluminum salts, ductal keratins, and mucopolysaccharides.