Keratinocyte apoptosis induction

Keratinocyte apoptosis induction" does not refer to a single molecule or receptor but rather describes a biological process—specifically, the triggering of programmed cell death in keratinocytes. This process can be mediated by several molecular pathways and stimuli. For example, ultraviolet B (UVB) irradiation induces classic apoptotic changes in human keratinocytes through mechanisms involving p53 signaling and upregulation of pro-apoptotic proteins like those from the Bcl-2 family as well as increased surface expression of the Fas receptor. Activated T cells infiltrating the skin can also induce keratinocyte apoptosis via engagement of the Fas receptor after its upregulation by interferon-gamma. This mechanism plays a significant role in inflammatory skin conditions such as eczematous dermatitis. However, "keratinocyte apoptosis induction" itself is not a discrete therapeutic target but rather an outcome resulting from modulation of upstream targets like the Fas receptor or p53 pathway components.

Other names

Keratinocyte apoptosisApoptosis induction in keratinocytesKC apoptosis induction

Induction of apoptotic pathways via Fas receptor activation; DNA damage response (e.g., p53 pathway activation by UVB); Cytokine-mediated upregulation of death receptors (e.g., IFN-gamma increasing Fas expression)