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Keratinocyte associated protein 3 (KRTCAP3)
- Target
- KRTCAP3
- Molecular classification
- Membrane protein (Gene Ontology annotation), Protein coding gene, Other (not receptor/enzyme/transporter/classic target)
01
Overview
Keratinocyte associated protein 3 is a protein encoded by the *KRTCAP3* gene, located on human chromosome 2. It is predicted to be a membrane-associated protein highly expressed in tissues such as the gastrointestinal tract and has cytoplasmic distribution[8]. In rodents, *Krtcap3* expression influences body weight, adiposity, food intake, and metabolic traits. Higher liver expression appears protective against obesity, and *Krtcap3*-deficient animals show sex- and genotype-specific metabolic effects[9]. In humans, genetic variation in *KRTCAP3* is associated with phenotypes including obesity, type 2 diabetes, and dyslipidemia[9]. Its precise biochemical function is not fully characterized, and it is not considered a therapeutic drug target at present[7][9].
- Other names
- KCP3MRV222PRO9898KRTCAP3Keratinocyte-associated protein 3
02
Biological functions
Structural component of epithelial and hair tissuesMay play a role in the formation, differentiation, and maintenance of keratinized tissuesRegulation of body weight and adiposity in preclinical studies
03
Disease associations
Obesity, metabolic disease risk, type 2 diabetes, and dyslipidemia based on genetic association studiesShort-rib thoracic dysplasia 10 with or without polydactyly (gene-disease association)Retinitis pigmentosa 71 (gene-disease association)
04
Safety considerations
No safety concerns documented, as it is not targeted pharmacologically
05
Biomarkers
Potential genetic marker for obesity, visceral fat mass, and metabolic syndrome riskNot established as clinical biomarker
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