Keratinocyte barrier function

**Keratinocyte barrier function** refers to the collective set of biological processes and molecular components in keratinocytes that together form and maintain the skin’s physical, chemical, and immune barrier. Key molecular contributors include structural proteins (e.g., keratins, filaggrin, loricrin, involucrin), lipids, tight junctions, enzymes, and immune mediators. Disruption in these processes or molecules compromises barrier integrity, leading to increased water loss, susceptibility to infections, and the development of inflammatory diseases such as atopic dermatitis or ichthyosis[1][2][3][4][5].

Other names

Epidermal barrier functionSkin barrier functionCutaneous barrier function