Keratinocyte cell turnover

Keratinocyte cell turnover refers to the continuous process in which keratinocyte stem cells divide in the basal layer of the epidermis, differentiate as they migrate toward the surface, and eventually undergo terminal differentiation and programmed cell death to form the stratum corneum[2][4][1][3][6]. This process is vital for maintaining skin integrity, barrier function, and resistance to environmental insults. Disruption of keratinocyte turnover is implicated in numerous dermatological diseases, aging, and impaired wound healing[1][2][6]. The rate of keratinocyte renewal decreases with age and may be modulated by topical drugs used in dermatology[4][6]. Note: "Keratinocyte cell turnover" is a biological process, not a specific molecular entity (e.g., receptor, enzyme, or transporter), so precise annotation per your target structure is not applicable. For molecular targeting, consider specific proteins or pathways regulating this process, such as Epidermal growth factor receptor (EGFR), Notch signaling components, or ΔNp63α[3][5].

Other names

keratinocyte lifecycleepidermal cell turnoverskin cell renewalkeratinocyte differentiationepidermal renewal

Modulation of keratinocyte proliferation/differentiation; Induction of apoptosis in abnormal cells; Enhancement of cell shedding from the stratum corneum