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Keratinocyte Desmosome Disruption
- Molecular classification
- Cell adhesion molecules, Desmosomes, Cadherins
01
Overview
Keratinocyte desmosome disruption refers to the process by which alpha hydroxy acids (AHAs) weaken the adhesive structures (desmosomes/corneodesmosomes) between keratinocytes in the epidermis. This disruption is primarily achieved through chelation of calcium ions necessary for desmosomal cadherin function and modulation of intracellular calcium levels, leading to increased cell turnover and exfoliation. This process is targeted by AHAs for cosmetic and therapeutic applications such as chemical peels, acne treatment, and anti-aging.
- Other names
- Corneodesmosome disruptionKeratinocyte cell adhesion disruptionDesquamation via alpha hydroxy acids
02
Mechanism of action
Chelation of calcium ions from desmosomal cadherins, leading to disruption of cell-cell adhesion; Intracellular acidification and TRPV3 activation, promoting apoptosis.
03
Biological functions
Cell adhesionCell turnoverDesquamationEpithelial barrier functionApoptosis
04
Disease associations
AcnePhotoagingHyperkeratosisSkin aging
05
Safety considerations
Skin irritationIncreased sun sensitivityImpaired barrier function with overuse
06
Interacting drugs
Glycolic acid
2 more in the full profile.
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