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Keratinocyte Desquamation

Molecular classification: Biological Process

Overview

Keratinocyte desquamation is the physiological process by which dead, terminally differentiated keratinocytes (corneocytes) are shed from the outermost layer of the skin, known as the stratum corneum. This process is essential for maintaining skin barrier function, thickness, and self-renewal. It involves a complex interplay of adhesion structures (corneodesmosomes), proteolytic enzymes (KLKs), and their inhibitors (LEKTI), regulated by pH gradients and various signaling molecules. Dysregulation of desquamation leads to skin disorders such as scaling and hyperkeratosis.

Other names: Skin sheddingCorneocyte sheddingEpidermal turnover

Biological functions

Maintenance of skin barrier functionRegulation of epidermal thicknessSkin self-renewalRemoval of dead cellsHydration

Disease associations

Scaling disordersHyperkeratosisNetherton syndrome

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