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Target intelligence / Profile preview
Fibroblast Growth Factor (None)
- Target
- None
- Molecular classification
- Cytokine, Growth Factor, Signaling Protein, Secreted Protein
01
Overview
Fibroblast growth factors (FGFs) are a family of cell signaling proteins that play essential roles in numerous biological processes, including cell proliferation, survival, migration, differentiation, angiogenesis, wound healing, embryonic development, and tissue regeneration. They act by binding to fibroblast growth factor receptors (FGFRs), transmembrane tyrosine kinase receptors, activating intracellular signaling pathways.
- Other names
- FGFaFGFbFGFAcidic Fibroblast Growth FactorBasic Fibroblast Growth FactorKeratinocyte Growth FactorFGF2FGF7
02
Mechanism of action
FGFs bind to FGFRs (tyrosine kinase receptors), activating downstream signaling pathways such as RAS/MAPK, PI3K/AKT, PLCγ, and STAT, leading to diverse cellular responses.
03
Biological functions
Cell proliferationCell survivalCell migrationCell differentiationAngiogenesisWound healingEmbryonic developmentTissue regenerationStem cell maintenanceMitogenesis
04
Disease associations
CancerCardiovascular diseaseOsteoarthritisDiabetes mellitusParkinson’s diseaseHypophosphatemiaPituitary disordersPediatric syndromes
05
Safety considerations
Potential for tumorigenesis via enhanced proliferation or angiogenesisRapid degradation of free FGFs at wound sitesOff-target effects due to promiscuous receptor bindingSystemic toxicity
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