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Target intelligence / Profile preview
Keratinocyte Growth Factor Receptor (FGFR2)
- Target
- FGFR2
- Molecular classification
- Receptor, Transmembrane Tyrosine Kinase
01
Overview
Keratinocyte growth factor receptor (FGFR2) is a transmembrane tyrosine kinase receptor belonging to the fibroblast growth factor receptor family. It plays a crucial role in cell proliferation, differentiation, mitogenesis, tissue repair, and embryonic development by binding to fibroblast growth factors and initiating downstream signaling cascades. Mutations and dysregulation of FGFR2 are associated with various congenital disorders and cancers.
- Other names
- Fibroblast Growth Factor Receptor 2CD332
02
Mechanism of action
Tyrosine kinase inhibition (for targeted therapies)
03
Biological functions
Cell proliferationCell differentiationMitogenesisTissue repairEmbryonic developmentSignal transduction
04
Disease associations
Craniosynostosis Syndromes (e.g., Apert Syndrome)LADD SyndromeCancerDevelopmental Anomalies
05
Safety considerations
Potential for off-target effects due to kinase inhibitors affecting other kinasesDevelopmental toxicityResistance mechanismsHyperphosphatemiaRetinal pigment epithelial detachment
06
Biomarkers
FGFR2 mutations (e.g., Ser252Trp, Pro253Arg)FGFR2 overexpression
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