Keratinocyte proliferation targets

"Keratinocyte proliferation targets" refers to the network of genes, proteins, and signaling molecules that regulate the multiplication and cell cycle progression of keratinocytes in the epidermis. Key regulators include transcription factors (such as p63, c-MYC), signaling pathways (Wnt/β-catenin, PI3K/Akt, Notch), and specific keratin proteins (K5, K14, K17). These molecules collectively balance keratinocyte growth and differentiation, essential for epidermal homeostasis, wound healing, and barrier function. Dysregulation of these targets is linked to increased risk of skin cancers (e.g., squamous cell carcinoma, basal cell carcinoma), skin disorders (e.g., psoriasis, delayed wound healing), and abnormal responses to microbial colonization. However, "keratinocyte proliferation targets" does not denote a single molecular entity and is not a valid canonical target name[1][2][3][4][5][6][7].