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Keratinocyte proline-rich protein (KPRP)
- Target
- KPRP
- Molecular classification
- Other (structural protein, not a receptor, channel, enzyme, nor transcription factor), Epidermal marker protein, Proline-rich protein
01
Overview
Keratinocyte proline-rich protein (KPRP) is a skin-specific, proline-rich structural protein expressed in the epidermis, particularly in the granular layers of the skin and periderm of fetal skin. It is implicated in keratinocyte differentiation and is thought to support epidermal barrier formation and function. Decreased expression is observed in atopic dermatitis lesions compared to normal skin, suggesting a possible role in skin disease. KPRP has been associated genetically with certain cancers, but its function in oncogenesis remains to be determined. There is currently no evidence supporting its role as a receptor, enzyme, or classic pharmacological target, and no approved drugs interact with this protein.
- Other names
- C1orf45hKPRPkeratinocyte expressed proline-rich proteinkeratinocyte proline-rich protein
02
Biological functions
Keratinocyte differentiationStructural role in the epidermisModulation of epidermal immune and barrier functions
03
Disease associations
Cancer (associated with prostate cancer and pancreatic squamous cell carcinoma in genetic studies; no functional disease implication currently established)Other (possible involvement in atopic dermatitis, as expression is decreased in this skin disease)
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