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Keratolytic Action
- Molecular classification
- Pharmacologic Effect
01
Overview
"Keratolytic action" describes a pharmacologic effect—primarily at the tissue level—rather than a specific molecular target/receptor. It involves breaking down excess keratinized tissue via chemical disruption at cellular junctions within the outermost layers of epidermis.
02
Mechanism of action
Softens/disrupts keratin & cell bonds; promotes shedding
03
Biological functions
ExfoliationDesquamationKeratin softeningDisruption of intercellular bonds
04
Disease associations
AcnePsoriasisEczemaDandruff/seborrheic dermatitisWartsCalluses/cornsHyperkeratosis
05
Safety considerations
IrritationExcessive peelingAllergic reactionsIncreased sensitivityContraindicated on open wounds
06
Interacting drugs
Salicylic acid
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