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Ketohexokinase isoform C (KHK-C)
- Target
- KHK-C
- Molecular classification
- Enzyme, Kinase
01
Overview
Ketohexokinase isoform C (KHK-C) is the major isoform of ketohexokinase (fructokinase) responsible for hepatic fructose metabolism. It catalyzes the phosphorylation of fructose to fructose 1-phosphate, the first committed step in fructolysis. KHK-C is highly expressed in the liver and kidney, and its activity bypasses key regulatory steps in glycolysis, potentially contributing to increased lipogenesis and metabolic disorders. As such, KHK-C is considered a potential therapeutic target for the treatment of obesity, metabolic syndrome, and related conditions.
- Other names
- FructokinaseKHK-C isoformHepatic fructokinase
02
Mechanism of action
Inhibition of fructose phosphorylation, reduction of fructose 1-phosphate production
03
Biological functions
Fructose metabolismFructolysisPhosphorylation of fructoseRegulation of glucokinase activityLipogenesis
04
Disease associations
Metabolic syndromeObesityFructosuriaDiabetes
05
Safety considerations
Potential for off-target effects on other kinasesUnintended consequences on glucose metabolismDevelopment of drug resistance
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