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Target intelligence / Profile preview
Keyhole Limpet Hemocyanin (KLH)
- Target
- KLH
- Molecular classification
- Metalloprotein, Glycoprotein, Oxygen Transport Protein, Immunostimulant, Carrier Protein
01
Overview
Keyhole limpet hemocyanin (KLH) is a large, multisubunit, oxygen-carrying metalloprotein found in the hemolymph of the giant keyhole limpet (*Megathura crenulata*). It is used as an immunostimulant and carrier protein in biomedical applications, particularly in vaccine development. KLH enhances the immune response to weakly antigenic substances and has been investigated in cancer immunotherapy. Two major isoforms exist: KLH1/KLH-A and KLH2/KLH-B, which differ slightly in their structure and oxygen binding affinity.
- Other names
- Keyhole limpet haemocyaninKLH1KLH2KLH-AKLH-B
02
Mechanism of action
Acts as an immune stimulant and carrier protein, enhancing the immune response to weakly antigenic substances. In cancer vaccines, it helps to stimulate an immune response against tumor-associated antigens.
03
Biological functions
Oxygen transportImmune stimulationAntigen carrier
04
Disease associations
Cancer (as a component of cancer vaccines)Schistosomiasis (diagnosis)Drug addiction (potential treatment)Inflammation (research)
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