Kidney function regulation via TCM principle

The “kidney function regulation via TCM principle” describes a body-wide concept in traditional Chinese medicine wherein the “kidney” is not equivalent to the anatomical organ but represents critical physiological functions involving water metabolism, bone health, reproduction, growth, and aging[1][2][3][4]. TCM theorizes links like the “Kidneys govern bones” principle, which translates—only metaphorically—to molecular concepts like the HPG axis, sex hormone action, and the Klotho-FGF23 axis in regulating calcium-phosphate homeostasis[1][2]. Therapeutic interventions in TCM focus on strengthening “kidney essence” using herbal compounds, matched to syndromes such as “kidney deficiency,” but these are systemic interventions rather than targeting specific molecules or receptors[1][2][4]. In modern translational research, scientists attempt to interpret these TCM principles via known hormone receptors, signaling pathways, and endocrine axes, but the TCM entity itself is not a singular, defined molecular therapeutic target[1][2][4].

Other names

“Kidneys govern bones” theoryKidney essence regulationKidney-Tian gui-vital essence-reproductive function axis

Modulation of hormonal receptors and axes (HPG axis, sex hormones) Regulation of calcium-phosphate metabolism through vitamin D and Klotho/FGF23 signaling Anti-inflammatory, antioxidant, and mitochondrial protection via herbal compounds