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Kidney tissue replacement by organ transplantation
- Molecular classification
- Other
01
Overview
"Kidney tissue replacement by organ transplantation" refers to the **surgical procedure** in which a healthy kidney from a living or deceased donor is transplanted into a patient with end-stage renal disease or irreversible kidney failure. The transplanted kidney takes over the filtration and regulatory functions lost by the patient's own kidneys. This process requires lifelong use of immunosuppressive drugs to prevent immune-mediated rejection of the new organ, which introduces risks such as infection and malignancy. The term does not refer to a specific molecule, receptor, enzyme, transporter, or other canonical therapeutic target but rather describes an entire medical intervention involving complex surgical and pharmacological management.[1][3][5]
- Other names
- Kidney transplantRenal transplantKidney allograftKidney graft
02
Mechanism of action
Suppression of immune response to prevent organ rejection
03
Biological functions
Other (Kidney transplantation is a surgical procedure, not a molecular or cellular function)
04
Disease associations
End-stage renal disease (ESRD)Chronic kidney diseasePolycystic kidney diseaseChronic glomerulonephritis
05
Safety considerations
Risk of infection due to immunosuppressionIncreased risk of cancer due to long-term immunosuppressionGraft rejection (cellular and antibody-mediated)
06
Interacting drugs
Immunosuppressants (e.g., tacrolimus/Prograf, steroids)
07
Biomarkers
Serum creatinine (for monitoring graft function)
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