Kidney yin-yang balance

The concept of **kidney yin-yang balance** originates from TCM theory, referring to the dynamic equilibrium of opposing forces: *Yin* (associated with internal, cooling, nourishing, and stabilizing qualities) and *Yang* (external, warming, energizing, and functional qualities) in kidney physiology. These forces underpin the diagnosis, classification, and treatment of diseases within TCM, with imbalance leading to pathological states such as kidney deficiency syndromes and chronic diseases[1][6]. TCM herbal formulas classified as "tonifying kidney yin" (e.g., Mingmu Dihuang pill) or "tonifying kidney yang" (e.g., Jingui Shenqi pill) are believed to restore this balance, acting by modulating immune responses, oxidative stress, inflammation, and signaling pathways. This framework informs therapeutic approaches for chronic kidney disease, diabetes-associated nephropathy, osteoarthritis, and even cancer, but does not translate directly to molecular or receptor targets used in Western medicine[1][2][3][4][5][6]. **Summary of why this entry is incorrect:** "Kidney yin-yang balance" is not a defined molecular target—it is a TCM theoretical concept, not a protein, gene, or canonical drug target. It cannot be classified under modern molecular families, lacks a standard abbreviation, and is not accompanied by specific biomarkers or molecular mechanisms in the sense used for other drug targets. However, it is central to how TCM approaches kidney-related diseases and therapy[1][6].

Other names

Kidney yin-yang harmonyYin-Yang balance in the kidneyKidney Yin and Yang

Multi-component regulation of signaling pathways (e.g., NF-κB, MAPK, JAK/STAT, PPAR); Modulation of inflammation and oxidative stress; Immunoregulation (Th1/Th2/Th17/Treg balance); Renal fibrosis inhibition; Regulation of electrolyte and water balance.