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In TCM theory, the kidneys are regarded as the "center of the body's yin and yang," sometimes called the congenital foundation or origin of life[1][3]. "Kidney yin" (primordial yin, true water) is described as the source of all yin fluid in the body, responsible for nourishing and moisturizing organs and tissues, while "kidney yang" (primordial yang, true fire) provides warmth and enables physiological functions[1][3]. Health is believed to depend on the dynamic interaction and balance of these two fundamental forces, which, when disrupted, may result in symptoms such as heat, dryness, fatigue, and other imbalances classified as "kidney yin deficiency" or "kidney yang deficiency"[7]. TCM treatments—including herbal medicines, acupuncture, and dietary modifications—aim to restore kidney yin-yang balance, but these interventions target whole-body functions rather than specific molecular entities[1][2][5][6][8]. The terminology represents a *diagnostic and therapeutic principle* rooted in TCM philosophy and does not map to a modern molecular or receptor-level target suitable for structured pharmacological annotation. No canonical abbreviation or biomolecular synonym exists. There is no corresponding list of drugs, mechanisms, biomarkers, or safety concerns in pharmacological databases. If molecular targets are required for drug discovery or clinical research annotation, a specific protein, enzyme, receptor, or known compound must be named. The current entry is best handled as a medical/philosophical construct, not a molecular entity. This entry is considered **incorrect** for molecular target mapping and should not be entered as such in structured molecular databases[3][4][5].
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