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Target intelligence / Profile preview
KIF26B antisense RNA 1 (KIF26B-AS1)
- Target
- KIF26B-AS1
- Molecular classification
- Other (long non-coding RNA, lncRNA)
01
Overview
KIF26B antisense RNA 1 (KIF26B-AS1) is a long non-coding RNA transcribed antisense to the protein-coding KIF26B gene. It is overexpressed in several cancers, notably laryngeal cancer, where it promotes cell proliferation and migration. Mechanistically, KIF26B-AS1 activates the toll-like receptor 4 (TLR4) signaling pathway by recruiting the RNA-binding protein FUS to stabilize TLR4 mRNA, enhancing the pathway's activity. These findings suggest that KIF26B-AS1 acts as an oncogenic lncRNA and may serve as a potential biomarker or therapeutic target for certain cancers, but it is not a conventional therapeutic target like a receptor or enzyme[2][3][6].
- Other names
- RP11-62I21.1KIF26B-AS1
02
Biological functions
Regulation of cell proliferationRegulation of cell migrationRegulation of gene expressionModulation of TLR4 signaling pathway
03
Disease associations
Cancer (notably laryngeal cancer)
04
Biomarkers
Potential as an oncogenic biomarker in laryngeal cancer
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