Killer cell immunoglobulin-like receptor, two Ig domains and short cytoplasmic tail 2 (KIR2DS2)

Killer cell immunoglobulin-like receptor, two Ig domains and short cytoplasmic tail 2 (KIR2DS2) is a member of the KIR gene family, encoding a type I transmembrane glycoprotein found on the surface of natural killer (NK) cells and some T cells[1][3]. KIR2DS2 is classified as an activating receptor (short cytoplasmic tail), lacking ITIM motifs and instead signaling through adaptor proteins to activate NK cells[1]. It features two extracellular immunoglobulin-like domains. KIR2DS2 specifically recognizes subsets of HLA class I molecules, particularly HLA-A*11:01, and its interaction with HLA is influenced by the peptide presented and certain key residues[2]. The KIR2DS2/HLA interaction regulates innate immune responses, contributing to pathogen immunity and, in some contexts, to cancer surveillance and autoimmunity. High polymorphism and complex gene copy number variation characterize this family, adding to the variable expression and function of KIR2DS2 in different individuals[1][3]. If you need more specific clinical or drug development information related to KIR2DS2, please clarify the therapeutic area of interest.

Other names

CD158j (occasional)KI2S2 (UniProt)Killer cell Ig-like receptor 2DS2KIR2DS2 gene

Modulating KIR2DS2 could affect NK cell activation by altering recognition of HLA ligands, leading to increased or decreased cytotoxic activity