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Target intelligence / Profile preview
Killer-cell immunoglobulin-like receptor 2DL1 (KIR2DL1)
- Target
- KIR2DL1
- Molecular classification
- Transmembrane glycoprotein, Receptor, Killer cell immunoglobulin-like receptor family
01
Overview
Killer-cell immunoglobulin-like receptor 2DL1 (KIR2DL1) is a transmembrane glycoprotein expressed on natural killer (NK) cells and some T cell subsets. It functions as an inhibitory receptor, binding to HLA-C group C2 allotypes (Cw4/Cw6/C*02) to prevent NK cell activation and lysis of target cells. KIR2DL1 plays a role in self-tolerance, infection control, autoimmunity avoidance, pregnancy tolerance, transplantation outcomes, and cancer surveillance. Genetic variation in KIR2DL1 and its ligands influences individual immune responses.
02
Mechanism of action
Inhibits NK cell activation and prevents lysis of target cells expressing specific HLA molecules.
03
Biological functions
Immune responseRegulation of NK cell activityInhibitory signaling
04
Disease associations
Infection controlAutoimmunityPregnancy toleranceTransplantationCancer surveillanceHIV infection
05
Safety considerations
Genetic variation influences individual immune responses.Potential for autoimmunity if inhibition is compromised.
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