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Target intelligence / Profile preview
Killer-cell Immunoglobulin-like Receptor 2DL2 (KIR2DL2)
- Target
- KIR2DL2
- Molecular classification
- Receptor, Transmembrane glycoprotein, Immunoglobulin-like receptor
01
Overview
KIR2DL2 is an inhibitory receptor expressed on NK cells and some T cells that recognizes HLA-C allotypes, primarily HLA-C group 1 (C1) alleles. Upon binding its ligand, KIR2DL2 inhibits NK cell cytotoxic activity, preventing the lysis of healthy host cells. Genetic variations in KIR2DL2 and its ligands are associated with susceptibility to infectious diseases and autoimmune disorders. Its function in modulating adaptive immunity makes it a complex target with potential for both protective and detrimental effects in chronic infections.
- Other names
- Natural killer-associated transcript 6p58 natural killer cell receptor clone CL-43MHC class I NK cell receptorCD158 antigen-like family member B1
02
Mechanism of action
N/A
03
Biological functions
Immune responseInhibition of NK cell cytotoxicityRegulation of innate immunityModulation of adaptive immunity
04
Disease associations
Infectious diseasesAutoimmunity
05
Safety considerations
Potential for unintended immunosuppressionComplex genetic polymorphism affecting ligand recognition
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