Killer cell lectin-like receptor C4 (KLRC4)

Killer cell lectin-like receptor C4 (KLRC4), also known as NKG2-F, is a member of the NKG2 family of C-type lectin receptors predominantly expressed on natural killer (NK) cells[1][2][3][5][6][8]. It encodes a type II integral membrane protein with a C-type lectin domain, involved in the modulation of NK cell activation and innate immune surveillance[1][2][6]. KLRC4 is structurally characterized by a charged residue in its transmembrane region, an ITIM-like motif, and a truncated extracellular domain compared to other NKG2 receptors[4][8]. While its natural ligand is not definitively identified, it is suggested to be involved in recognition of MHC class I, possibly HLA-E, and can associate with the signaling adaptor DAP12, implying an activating potential for NK cells[4][8]. Genetic variants in KLRC4 have been linked to susceptibility to immune-mediated diseases (e.g., Behçet’s disease), leukemia prognosis, and inflammatory diseases, and its expression may be used as a biomarker for NK cell activity and disease progression[2][6][8]. However, the full physiological and therapeutic significance of KLRC4 remains the subject of ongoing research.

Other names

NKG2-FNKG2FNKG2-F type II integral membrane proteinNK cell receptor FNKG2-F-activating NK receptorkiller cell lectin-like receptor subfamily C member 4natural killer cell group 2-F