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Target intelligence / Profile preview
Killer Cell Lectin-like Receptor G1 (KLRG1)
- Target
- KLRG1
- Molecular classification
- C-type lectin, Type II transmembrane protein, Receptor
01
Overview
Killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed on NK cells, CD8+ T cells, CD4+ T cells, and Tregs. It binds to classical cadherins (E-, N-, R-cadherins) and inhibits immune cell activation through recruitment of SHP-1/SHIP-1 phosphatases via its ITIM domain. KLRG1 is often used as a marker of terminal differentiation or senescence in lymphocytes, and it plays a role in regulating immune responses in chronic infections, cancer, and vaccination.
02
Mechanism of action
Blockade of KLRG1 interaction with cadherin ligands, preventing SHP/SHIP recruitment and downstream inhibitory signaling
03
Biological functions
Inhibitory immune checkpointImmune regulationCell differentiationCell senescenceNK cell inhibitionT cell inhibition
04
Disease associations
Infectious diseasesCancerImmune dysregulation
05
Safety considerations
Potential for autoimmunity or immune-related adverse events with KLRG1 blockade
06
Interacting drugs
KLRG1 blocking antibodies
07
Biomarkers
KLRG1 expression level on immune cells (NK, CD8+ T, CD4+ T, Tregs)
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